Abrysvo
This is one of the vaccines that protects against RSV
Active ingredients:
The active ingredients in this vaccine are recombinant RSV PreF A and RSV PreF B antigens.
RSV PreF is a glycoprotein (a protein with a sugar attached to it). The two antigens protect against the two main types of RSV: A and B.
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This is a recombinant protein vaccine, which means that the instructions to make are inserted into the genome of cells so that they produce the proteins.
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Note: this vaccine contains trace amounts of DNA and proteins from the cells used to produce the surface antigen. These cells are Chinese hamster ovary cells.
Inactive ingredients:
Amounts are based on a 0.5 mL dose
Salts: help maintain the stability and pH of the vaccine
Carbohydrates (sugars): normally used as stabilizers in vaccines
Other Stabilizers:
Relevant Terms
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Antibody: a protein made by the immune system in response to a foreign particle (antigen). These proteins circulate in the blood and help defend the body against the substance.
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Antigen: This is any substance that triggers the immune system to create antibodies. For example, allergens such as pollen are antigens.
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Attenuated: The pathogen is weakened but not completely inactivated. Attenuated pathogens are too weak to cause disease in almost all people.
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Genome: all of the genetic information in a cell.
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pH: a measure of how acidic or basic a solution is. The scale ranges from 0 (very acidic) to 14 (very basic). A pH of 7 is neutral.
Sources
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Package insert: https://www.fda.gov/media/168889/download?attachment
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General:
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Sodium chloride: https://www.health.harvard.edu/newsletter_article/sodium-salt-and-you
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Mannitol:
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Tromethamine:
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Sucrose (sugar)​
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Polysorbate 80:
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https://www.chop.edu/centers-programs/vaccine-education-center/vaccine-ingredients
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Last updated: Sep. 9, 2023