Daptacel
This vaccine protects against diphtheria, tetanus, and pertussis
Ingredients:
Active ingredients:
Tetanus toxoid, diphtheria toxoid, and detoxified pertussis toxin, filamentous hemagglutinin (a cell surface protein), pertactin (outer membrane protein), and fimbriae types 2 and 3 (parts of the bacterium that allow it to attach to host cells)
Inactive ingredients:
Amounts are based on a 0.5 mL dose
Adjuvants: strengthen the immune response to the vaccine
Ingredients From Manufacturing: used to prevent contamination and inactivate bacterial toxins.
Relevant Terms:
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Antibody: A protein made by the immune system in response to a foreign particle (antigen). These proteins circulate in the blood and help defend the body against the substance.
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Antigen: This is any substance that triggers the immune system to create antibodies. For example, allergens such as pollen are antigens.
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Antitoxin: An antibody that neutralizes toxins
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Bacterium: The singular of bacteria (one bacterium, two bacteria)
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Toxoid: An inactive version of a toxin produced by a bacterium. The body is able to make antitoxin without being exposed to the actual toxin. Toxoids are not toxic.
Sources
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Package insert: https://www.fda.gov/files/vaccines%2C%20blood%20%26%20biologics/published/Package-Insert---DAPTACEL.pdf
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General:
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Filamentous hemagglutinin: https://pubmed.ncbi.nlm.nih.gov/2294058/
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Antibody: https://www.genome.gov/genetics-glossary/Antibodyhttps://www.genome.gov/genetics-glossary/Antibody
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Antitoxin: https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/antitoxin
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Toxoid: https://www.sciencedirect.com/topics/neuroscience/toxoid
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​Aluminum:
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Formaldehyde: https://www.chop.edu/centers-programs/vaccine-education-center/vaccine-ingredients/formaldehyde
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Glutaraldehyde: https://www.medicines.org.uk/emc/product/3758/smpc#gref
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2-phenoxyethanol: https://pubchem.ncbi.nlm.nih.gov/compound/2-Phenoxyethanol​​​
Last updated: Mar. 2, 2023