Havrix

This is one of the hepatitis A vaccines

Relevant Terms

• Antibiotics: substances that kill bacteria or prevent them from dividing. Antibiotics are used in some vaccines to prevent contamination during the manufacturing process.

• Emulsifier: a substance that helps to keep the ingredients mixed together

• MRC-5 cells: This is a human cell line that is used to help grow active ingredients for vaccines

• pH: a measure of how acidic or basic a solution is. The scale ranges from 0 (very acidic) to 14 (very basic). A pH of 7 is neutral.

• Package insert: https://www.fda.gov/media/119388/download

• ​General:​

  • https://vk.ovg.ox.ac.uk/vk/vaccine-ingredients

  • https://www.chop.edu/centers-programs/vaccine-education-center/vaccine-ingredients/antibiotics

  • https://www.fda.gov/drugs/electronic-drug-registration-and-listing-system-edrls/strength-conversion-drug-listing

  • https://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/display.files/fileid/14285

  • ​https://www.usgs.gov/special-topics/water-science-school/science/water-density

• Aluminum: 

  • https://www.cdc.gov/vaccinesafety/concerns/adjuvants.html

  • https://www.chop.edu/centers-programs/vaccine-education-center/vaccine-ingredients/aluminum

  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940618/

  • https://fdc.nal.usda.gov/fdc-app.html#/food-details/1999632/nutrients

• Aluminum hydroxide: https://medlineplus.gov/druginfo/meds/a601013.html

• Amino acid supplement:

  • https://medlineplus.gov/ency/article/002222.htm

  • https://fdc.nal.usda.gov/fdc-app.html#/food-details/747997/nutrients

  • ​https://www.fda.gov/vaccines-blood-biologics/safety-availability-biologics/common-ingredients-us-licensed-vaccines

• Neomycin: https://www.mayoclinic.org/drugs-supplements/neomycin-oral-route/proper-use/drg-20065027?p=1

• PBS: 

  • https://academic.oup.com/labmed/article/40/5/290/2657559

  • https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c64ed4c0-1e27-42b3-9625-fb4e0d31e271

  • https://www.fda.gov/files/drugs/published/Drug-Shortages--Sodium-Phosphate-Notification-Letter.pdf

  • https://www.health.harvard.edu/newsletter_article/sodium-salt-and-you

• Polysorbate 20: 

  • https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/polysorbate-20

  • https://www.fao.org/3/y0474s/y0474s5a.htm

• Formalin: 

  • https://www.chop.edu/centers-programs/vaccine-education-center/vaccine-ingredients/formaldehyde

  • ​https://microscopy.duke.edu/guides/paraformaldehyde-formaldehyde-formalin