Kinrix
This vaccine protects against diphtheria, tetanus, pertussis, and polio.
Ingredients:
Active ingredients:
Diphtheria toxoid, tetanus toxoid, inactivated pertussis toxin, filamentous hemagglutinin (a cell surface protein), pertactin (outer membrane protein), inactivated type 1 poliovirus, inactivated type 2 poliovirus, and inactivated type 3 poliovirus.
Inactive ingredients:
Amounts are based on a 0.5 mL dose
Salts: help maintain the stability and pH of the vaccine
Adjuvants: strengthen the immune response to the vaccine
Antibiotics: used to prevent contamination during manufacturing
Other:
Relevant Terms:
-
Antibiotics: substances that kill bacteria or prevent them from dividing. Antibiotics are used in some vaccines to prevent contamination during the manufacturing process.
-
Antibody: a protein made by the immune system in response to a foreign particle (antigen). These proteins circulate in the blood and help defend the body against the substance.
-
Antigen: This is any substance that triggers the immune system to create antibodies. For example, allergens such as pollen are antigens.
-
Antitoxin: an antibody that neutralizes toxins
-
Bacterium: The singular of bacteria (one bacterium, two bacteria)
-
Emulsifier: a substance that helps to keep the ingredients mixed together
-
pH: a measure of how acidic or basic a solution is. The scale ranges from 0 (very acidic) to 14 (very basic). A pH of 7 is neutral.
-
Toxoid: an inactive version of a toxin produced by a bacterium. The body is able to make antitoxin without being exposed to the actual toxin. Toxoids are not toxic.
Sources
-
Package insert: https://www.fda.gov/media/80128/download
-
General:
-
Filamentous hemagglutinin: https://pubmed.ncbi.nlm.nih.gov/2294058/
-
Toxoid: https://www.sciencedirect.com/topics/neuroscience/toxoid
-
​Antibiotics:
-
​Aluminum:
-
Aluminum hydroxide: https://medlineplus.gov/druginfo/meds/a601013.html
-
Formaldehyde: https://www.chop.edu/centers-programs/vaccine-education-center/vaccine-ingredients/formaldehyde
-
Salt: https://www.health.harvard.edu/newsletter_article/sodium-salt-and-you
-
Polysorbate 80:
-
Neomycin: https://www.mayoclinic.org/drugs-supplements/neomycin-oral-route/proper-use/drg-20065027?p=1
-
Polymyxin B:
Last updated: Mar. 4, 2023