Pediarix
This vaccine protects against diphtheria, tetanus, pertussis, hepatitis B, and polio
Ingredients:
Active ingredients:
Diphtheria toxoid, tetanus toxoid, inactivated pertussis toxin, hepatitis B surface antigen, inactivated poliovirus virus, filamentous hemagglutinin (a cell surface protein), and pertactin (outer membrane protein)
Inactive ingredients:
Amounts are based on a 0.5 mL dose
Salts: help maintain the stability and pH of the vaccine
Adjuvants: strengthen the immune response to the vaccine
Antibiotics: used to prevent contamination during manufacturing
Other:
Relevant terms
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Antibiotics: substances that kill bacteria or prevent them from dividing. Antibiotics are used in some vaccines to prevent contamination during the manufacturing process.
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Antibody: a protein made by the immune system in response to a foreign particle (antigen). These proteins circulate in the blood and help defend the body against the substance
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Antigen: This is any substance that triggers the immune system to create antibodies. For example, allergens such as pollen are antigens
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Antitoxin: an antibody that neutralizes toxins
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Bacterium: The singular of bacteria (one bacterium, two bacteria)
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Emulsifier: a substance that helps to keep the ingredients mixed together
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pH: a measure of how acidic or basic a solution is. The scale ranges from 0 (very acidic) to 14 (very basic). A pH of 7 is neutral.
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Toxoid: an inactive version of a toxin produced by a bacterium. The body is able to make antitoxin without being exposed to the actual toxin. Toxoids are not toxic.
Sources
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Package insert: https://www.fda.gov/media/79830/download
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General:
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Filamentous hemagglutinin: https://pubmed.ncbi.nlm.nih.gov/2294058/
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Toxoid: https://www.sciencedirect.com/topics/neuroscience/toxoid
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Antibiotics:
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Aluminum:
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Aluminum hydroxide:
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Formaldehyde: https://www.chop.edu/centers-programs/vaccine-education-center/vaccine-ingredients/formaldehyde
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Salt: https://www.health.harvard.edu/newsletter_article/sodium-salt-and-you
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Polysorbate 80: https://www.chop.edu/centers-programs/vaccine-education-center/vaccine-ingredients
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Neomycin Sulfate:
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Polymyxin B Sulfate:
Last updated: July 9, 2024